Poor defence mechanism of the body allows several disease-causing germs to infect people with AIDS. Detailed below are some of the common opportunistic infections seen in people with AIDS.
Tuberculosis: This is a bacterial infection and is normally transmitted when a person with active tuberculosis coughs or sneezes. During the act of coughing or sneezing, germ particles of tuberculosis called droplet nuclei are released in the air. These droplet nuclei contain the bacteria that cause tuberculosis. When a healthy person inhales the droplet nuclei, he/she can get infected with tuberculosis. Many people in India who are infected with tuberculosis develop latent infection only. Latent infection means the infected person will neither have any signs or symptoms nor will be able to spread the infection to others. They can however, become sick and get infected with active tuberculosis at a later stage.
Tuberculosis often occurs in the early stages of HIV infection. Since tuberculosis is already one of the major health problems in India, people with HIV infection are at a higher risk of getting it. Very often, tuberculosis is the first indication that a person has HIV infection. Although tuberculosis largely affects the lungs, it can affect other organs of the body also. People with AIDS are more likely to get infection in other organs of the body.
One of the major concerns related to tuberculosis and AIDS is resistance of the tuberculosis bacteria to several medicines that were earlier effective for its treatment. Resistance of medicines normally occurs when people fail to complete a course of treatment. Since treatment for tuberculosis takes several months, there is a very high rate of drop-outs. People who fail to complete the full course of treatment can become resistant to medicines and spread the resistant bacteria to others also. Resistant tuberculosis is one of the important causes of early death in people with HIV infection.
Tuberculosis is more common in people with HIV infection who have less than two hundred CD4+ count.
Common symptoms of tuberculosis include cough, fever, increased sweating at nights, loss of weight and excessive fatigue.
AIDS dementia complex: This is not a true opportunistic infection. It is one of the few conditions caused directly by the HIV virus. HIV can cross the blood barrier present all around the brain. It can damage not only the brain but also the spinal cord— the main nerve that emerges from the base of the neck and passes through the backbone — and the nerves.
Common symptoms of AIDS dementia complex include confusion, depression and a strange unusual behaviour. There may be general loss of interest in the surroundings, indifference, etc. In later stages, it causes loss of memory, uncoordinated movements, or paralysis.
Diagnostic diseases: Kaposis’s sarcoma and cryptococcal meningitis are the two diseases that are a definite indication of AIDS.
Kaposis’s sarcoma: This is the most common cancer seen in people with AIDS. Some studies have indicated that this cancer is due to infection by one of the herpes groups of viruses. Some other studies have indicated that it is due to an abnormality of the production of blood cells. Although more studies are necessary to identify the cause of kaposis’s sarcoma, its presence is a definite indication of AIDS. Common symptoms of kaposis’s sarcoma include red or purple raised areas on the skin. They may also be present in internal organs of the body such as mouth, lymph nodes, digestive tract and lungs. Recent advances in management of kaposis’s sarcoma have increased the chances of complete recovery.
Cryptococcal meningitis: This infection is caused by a yeast-like fungus called cryptocossus neoformans. It is found in soil in most parts of the world, especially the soil that is contaminated with bird droppings. In the early stages of the infection, the fungus affects the brain and the lungs. In later stages, it can affect any other part of the body. Cryptococcal meningitis is more common among people with CD4 count less than fifty.
Common symptoms of cryptococcal meningitis include fever, mild headache followed by nausea, vomiting, severe headache and blurring of vision.
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